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  • Osteoarthritis Treatment on a New Zealand White Rabbit Model with Low Frequency-Low Intensity Ultrasound for Proceedings of the International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2014)   [iCBBE 2014]
  • Author(s)
  • Yi Wun Lin, IoannisManousakas, Shan-Wei Yang, Shyh Ming Kuo
  • ABSTRACT
  • Degeneration or injurieson articular cartilage is hard to self-repair. Physical stimulation, such as electrical, ultrasound or shear stress could be used for promoting chondrocytes proliferation and articular cartilage self-repair. Previous research on ultrasound stimulation used high frequency ultrasound.In thisstudy, low frequency ultrasound stimulation is proposedas the treatment of osteoarthritis.An osteoarthritis model using New Zealand Whiterabbits was used toinvestigate whether low frequency ultrasound stimulation of 32.8 kHzis effective for the regeneration of articular cartilage.The evidence shows that low frequency ultrasound of 100mW can promote the regeneration of articular cartilage.
  • KEYWORDS
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  • References
  • [1]
    Park. H. S, Yip. M. C., Chertok. B, Kost, J., Kobler. J. B., Langer. R. and Zeitels S. M. 2010. "Indirect Low-Intensity Ultrasonic Stimulation for Tissue Engineering," J Tissue Eng.
    [2]
    Park S. R., Jang K. W., Park S. H., Cho H. S., Jin C. Z., Choi M. J., Chung S. I. and Min B. H. 2005. "The effect of sonication on simulated osteoarthritis. Part I: effects of 1 MHz ultrasound on uptake of hyaluronan into the rabbit synovium.," Ultrasound Med Biol., 31(11):1551-1558.
    [3]
    Gurkan I, Ranganathan A, Yang X, Horton W. E. Jr, Todman M, Huckle J, Pleshko N and Spencer R. G. 2010."Modification of osteoarthritis in the guinea pig with pulsed low-intensity ultrasound treatment" Osteoarthritis Cartilage, 18(5): 724–733.

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