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Articles
  • Meta-analysis of Alzheimer's disease risk with waist circumference for Proceedings of the International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2014)   [iCBBE 2014]
  • Author(s)
  • M.Ch. Zhang, H. Cai, Ch. Li, Q.H. Du, S.Y. Liu
  • ABSTRACT
  • To analyze the association between the waist circumference (WC) and the risks of Alzheimer’s disease (AD), and to provide evidences for the prevention of AD.Related literatures were searched systematically and those that don't meet the requirement were excluded. All analyses were conducted using inverse variance method by Review Manager version 5.0 software. Compatible data in longitudinal prospective cohort studies were used for meta-analysis. The mean and standard error were analyzed based on the hazard ratio (HR) of different studies. The heterogeneity of the results was assessed by I2 index. I2 < 50% was identified as no significant heterogeneity and fixed model was applied. Otherwise, random model was used. Data were presented as combined HR value and 95% confidence interval (95%CI). HR > 1 indicated increased risks, while HR < 1 indicated protection.Results show that in Class I studies, HR was 0.62 with 95%CI ranged from 0.47 to 0.82, and I2 was 0%. The incidence of AD was reduced by 38% in male with WC over 102 cm, in female with WC over 88 cm. In Class II studies, HR was 0.94 with 95%CI ranged from 0.62 to 1.43, and I2 was 17%. No significant difference was found in the incidence of AD between high WC and low WC group (HR = 0.94).Wi concluded thate decreased AD risk was found in male with WC over 102 cm, in female with WC over 88 cm.
  • KEYWORDS
  • Dementia; Alzheimer’s disease (AD); vascular dementia (VaD); Waist circumference(WC); Meta-analysis
  • References
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