top
Articles
  • OpenAccess
  • Hydrophilic Silica/Copolymer Nanoparticles and Protein-Resistance Coatings  [PMS 2016]
  • DOI: 10.4236/msce.2016.41004   PP.18 - 23
  • Author(s)
  • Hongpu Huang, Ling He
  • ABSTRACT
  • Hydrophilic silica/copolymer nanoparticles of SiO2-g-P(PEGMA)-b-P(PEG) are prepared by silica surface-initiating atom transfer radical polymerization (SI-ATRP) of poly (ethylene glycol) methyl ether methacrylate (PEGMA) and poly(ethylene glycol) methacrylate (PEG), by using Three molar ratios of SiO2-Br/PEGMA/PEG as 1/42.46/19.44, 1/42.46/38.88 and 1/42.46/77.76. Their temperature sensitive behaviour, pH response and surface properties as protein-resistance coatings are characterized. 220 nm core-shell nanoparticles as P(PEGMA)-b-P(PEG) shell grafted on SiO2 core are formed in water solution, which gained LCST at 60C - 77C and good dispersion in water when pH > 5.0. The water-casted films by SiO2-g-P(PEGMA)-b-P(PEG) obtain a little rough surface (Ra = 26.8 - 29.7 nm). While, the introduction of P(PEG) segments could slight increase the protein-repelling adsorption of SiO2-g-P(PEGMA)-b-P(PEG) films (f = ?6.96 Hz ~ ?7.25 Hz) compared with SiO2-g-P(PEGMA) films (f = ?9.5 Hz). Therefore, SiO2-g-P(PEGMA)-b-P(PEG) could be used as protein-resistance coatings.

  • KEYWORDS
  • Silica/Copolymer, Hydrophilic Nanoparticles, Tem-Responsive, Protein-Resistance, Coatings
  • References
  • [1]
    Mustafa, B., Burak, Z.B., Mustafa, S.Y. and Mehmet, V.Y. (2015) Smart-Polymer-Functionalized Graphene Nanodevices for Thermo-Switch-Controlled Biodetection. Biomater. Sci. Eng, 1, 27-36.
    http://dx.doi.org/10.1021/ab500029h
    [2]
    Philippe, H.S., Bradley, A., Bruce, M.A. and Jeffrey, P.Y. (2007) Synergistic Activity of Hydrophilic Modification in Antibiotic Polymers. Biomacromolecules, 8, 19-23.
    http://dx.doi.org/10.1021/bm0605513
    [3]
    Sehmus, O., Liehui, G., Tharangattu, N.N., Amelia, H.C.H., Hyunseung, Y., Srividya, S., Robert, V. and Pulickel, M.A. (2014) Anisotropically Functionalized Carbon Nanotube Array Based Hygroscopic Scaffolds. Appl. Mater. Interfaces, 6, 10608-10613.
    http://dx.doi.org/10.1021/am5022717
    [4]
    Liu, Y.G., Qiu, Q., Shen, W.Q. and An, Z.S. (2011) Aqueous Dispersion Polymerization of 2-Methoxyethyl Acrylate for the Synthesis of Biocompatible Nanoparticles Using a Hydrophilic RAFT Polymer and a Redox Initiator. Macromolecules, 44, 5237-5245.
    http://dx.doi.org/10.1021/ma200984h
    [5]
    Oana, G.S., Georges, M.P., Hannes, P.E., Michael, A.R.M., Richard, H. and Ulrich, S.S. (2009)A Versatile Approach to Unimolecular Water-Soluble Carriers: ATRP of PEGMA with Hydrophobic Star-Shaped Polymeric Core Molecules as an Alternative for PEGylation. Macromolecules, 42, 1808-1816.
    http://dx.doi.org/10.1021/ma8024738
    [6]
    Zhu, X.B., Michael, F., Benjamin, T.D., Marc, A.I. and Bradford, B.W. (2012) Modifying the Hydrophilic-Hydrophobic Interface of PEG-b-PCL to Increase Micelle Stability: Preparation of PEG-b-PBO-b-PCL Triblock Copolymers, Micelle Formation, and Hydrolysis Kinetics. Macromolecules, 45, 660-665.
    http://dx.doi.org/10.1021/ma202530v
    [7]
    Torben, G., Canet, A., Lucio, I., Schlu, D.A., Nicholas, D.S. and Marcus, T. (2013) PEG-Stabilized Core-Shell Nanoparticles: Impact of Linear versus Dendritic Polymer Shell Archi-tecture on Colloidal Properties and the Reversibility of Temperature-Induced Aggregation. Nano, 7, 316-329.
    [8]
    Nakabayashi, K., Oya, H. and Mori, H. (2012) Cross-Linked Core-Shell Nanoparticles Based on Am-phiphilic Block Copolymers by RAFT Polymerization and Palladium-Catalyzed Suzuki Coupling Reaction. Macromo-lecules, 45, 3197-3204.
    http://dx.doi.org/10.1021/ma300239u
    [9]
    Cao, C.W., Yang, K., Wu, F., Wei, X.Q., Lu, L.C. and Cai, Y.L. (2010) Thermally Induced Swellability and Acid-Liable Dynamic Properties of Microgels of Copolymers Based on PEGMA and Aldehyde-Functionalized Monomer. Macromolecules, 43, 9511-9521.
    http://dx.doi.org/10.1021/ma1017549
    [10]
    Huang, C., Koon, G.N. and En, T.K. (2012) Combined ATRP and “Click” Chemistry for Designing Stable Tumor- Targeting Superparamagnetic Iron Oxide Nanoparticles. Langmuir, 28, 563-571.
    http://dx.doi.org/10.1021/la202441j
    [11]
    Guo, W.H., Zhu, J., Cheng, Z.P., Zhang, Z.B. and Zhu, X.L. (2011) Anti-coagulant Surface of 316 L Stainless Steel Modified by Surface-Initiated Atom Transfer Radical Polymerization. Appl. Mater. Interfaces, 3, 1675-1680.
    http://dx.doi.org/10.1021/am200215x
    [12]
    Liu, J.L., He, W.W., Zhang, L.F., Zhang, Z.B., Zhu, J. and Yuan, L. (2011) Bifunctional Nanoparticles with Fluorescence and Magnetism via Surface-Initiated AGET ATRP Mediated by an Iron Catalyst. Langmuir, 27, 12684-12692.
    http://dx.doi.org/10.1021/la202749v
    [13]
    Hazrat, H., Khine, Y.M. and Chaobin, H. (2008) Self-Assembly of Brush-Like Poly[poly(ethylene glycol) methyl ethermethacrylate] Synthesized via Aqueous Atom Transfer Radical Polymerization. Langmuir, 24, 13279-13286.
    http://dx.doi.org/10.1021/la802734e
    [14]
    Chen, X., Zhang, G.F., Zhang, H.Q., Zhan, X.L. and Chen, F.Q. (2015) Preparation and Performance of Amphiphilic Polyurethane Copolymers with Capsaicin-Mimic and PEG Moieties for Protein Resistance and Antibacteria. Ind. Eng. Chem. Res, 54, 3813-3820.
    http://dx.doi.org/10.1021/ie505062a
    [15]
    Kim, D.G., Kang, H., Han, S. and Lee, J.C. (2012) Dual Effective Organic/Inorganic Hybrid Star-Shaped Polymer Coatings on Ultrafiltration Membrane for Bio- and Oil-Fouling Resistance. Appl. Mater. Interfaces, 4, 5898-5906.
    http://dx.doi.org/10.1021/am301538h
    [16]
    Wetra, Y., Sophie, M., Pierre, T.M., Maureen, C.E., James, C.A., Lyndsey, T., Bo, L. and Thomas, E. (2014) Hydration and Chain Entanglement Determines the Optimum Thickness of Poly(HEMA-co-PEG10MA) Brushes for Effective Resistance to Settlement and Adhesion of Marine Fouling Organisms. Appl. Mater. Interfaces, 6, 11448-11458.
    http://dx.doi.org/10.1021/am502084x
    [17]
    Chang, Y., Shih, Y.J., Ko, Y.C., Jhong, F.J., Liu, Y.L. and Wei, T.C. (2011) Hemocompatibility of Poly(vinylidene fluoride) Membrane Grafted with Network-Like and Brush-Like Antifouling Layer Controlled via Plasma-Induced Surface PEGylation. Langmuir, 27, 5445-5455.
    http://dx.doi.org/10.1021/la1048369
    [18]
    Huang, H.P. and He, L. (2014) Silica-Diblock Fluoropolymer Hybrids Syn-thesized by Surface-Initiated Atom Transfer Radical Polymerization. RSC Adv, 4, 13108-13118.
    http://dx.doi.org/10.1039/c3ra47393g
    [19]
    Huang.H.P, Qu.J, He.L (2015) Amphiphilic Silica/Fluoropolymer Nano-particles: Synthesis,Tem-Responsive and Surface Properties as Protein-Resistance Coatings. Journal of Polymer Science, Part A: Polymer Science.
    http://dx.doi.org/10.1002/pola.27785
    [20]
    Marlene, L., Andre, M. and Christine, B. (2012) Fouling Release Coatings: A Nontoxic Alternative to Biocidal Anti-fouling Coatings. Chem. Rev., 112, 4347-4390.
    http://dx.doi.org/10.1021/cr200350v

Engineering Information Institute is the member of/source content provider to

http://www.scirp.org http://www.hanspub.org/ http://www.crossref.org/index.html http://www.oalib.com/ http://www.ebscohost.com/ http://www.proquest.co.uk/en-UK/aboutus/default.shtml http://ip-science.thomsonreuters.com/cgi-bin/jrnlst/jlresults.cgi?PC=MASTER&Full=journal%20of%20Bioequivalence%20%26%20Bioavailability http://publishers.indexcopernicus.com/index.php