• OpenAccess
  • Influence of Genetic Polymorphism of Styrene-Metablizing Enzymes on Occupational Exposure Monitoring to Styrene  [COME 2015]
  • DOI: 10.4236/jbm.2015.33005   PP.35 - 38
  • Author(s)
  • Wei Qu, Fang Zhang
  • In this study, we selected 58 styrene-exposed workers, measured personal styrene exposure, evaluated genotypes relevant drug-metabolizing enzymes (CYP2E1, EPHX1, GSTM1 and GSTT1) which may explain the variability in the urinary metabolite excretion. The results showed that, in different levels of styrene exposure groups, there is a significant association between urinary metabolites and some genotypes of styrene-metabolizing enzymes, including CYP2E1 (5-flanking region, RsaI/PstI), GSTM1(gene deletions) and EPHX1(predicted activity).

  • Styrene, Mandelic Acid (MA), Phenylglyoxylic Acid (PGA), Phenyl Hydroxyethyl Mercapturic Acids (PHEMA), Biological Monitoring, Genetic Polymorphisms
  • References
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    VeMina, A, Galati, R., Falasca, G., et al. (2001) Metabolic Polymorphisms and Urinary Biomarkers in Subjects with Low Benzene Exposure. Journal of Toxicology and Environmental Health, 64, 607-618.
    Kim, H., Wang, R.S., Elovaara, E., et al. (1997) Cytochrome P450 Isoenzymes Responsible for the Metabolism of Toluene and Styrene in Human Liver Microsomes. Xenobiotica, 27, 657-665.

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